Table 1 Association between FAS rs2234767, rs1800682 and FASLG rs763110 genotypes and risk of CRC.

From: FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin

SNPs

Genotype

Cases (n = 878)

Controls (n = 884)

P a

P b

Adjusted OR (95% CI)c

n

%

n

%

FASLG

CC

462

53

470

53

0.71

1.0

1.00 (Ref)

rs763110

CT

354

40

344

39

  

1.06 (0.87–1.28)

 

TT

62

7

70

8

  

0.90 (0.62–1.30)

 

P trend

      

0.92

 

T allele

478

27

484

27

0.92

1.0

 

FAS

GG

305

37

385

44

0.0051

0.015

1.00 (Ref)

rs2234767

GA

407

49

372

43

  

1.39 (1.13–1.71)

 

AA

124

15

114

13

  

1.37 (1.02–1.84)

 

P trend

      

0.0051

 

A allele

655

39

600

34

0.0042

0.013

 
 

GG

305

36

385

44

  

1.00 (Ref)

 

GA/AA

531

64

486

56

  

1.38 (1.14–1.68)

FAS

AA

301

34

348

40

0.060

0.18

1.00 (Ref)

rs1800682

AG

435

50

392

44

  

1.30 (1.06–1.60)

 

GG

142

16

144

16

  

1.16 (0.88–1.53)

 

P trend

      

0.14

 

G allele

719

41

680

38

0.13

0.39

 
 

AA

301

34

348

39

  

1.00 (Ref)

 

AG/GG

577

66

536

61

  

1.26 (1.04–1.53)

  1. Bold indicated statistically significant.
  2. aχ2 test for either genotype distributions or allele frequencies between the cases and controls.
  3. bAdjusted for multiple comparisons by Bonferroni correction.
  4. cAdjusted for age, sex, smoking and drinking status in logistic regression model.
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