Table 2 Combined genotype frequencies of the FAS polymorphisms among the cases and controls and their association with risk of CRC.

From: FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin

Combined genotypes

 

Cases (n = 836)

Controls (n = 871)

P a

Adjusted OR (95% CI)b

n (%)

n (%)

FAS rs2234767

FAS rs1800682

  

<0.001

 

GG

AA

287 (34)

347 (40)

 

1.00 (Reference)

GG

AG/GG

18 (2)

38 (3.9)

 

0.60 (0.33–1.07)

GA/AA

AA

13 (2)

1 (0.1)

 

15.49 (2.01–119.25)

GA/AA

AG/GG

518 (62)

485 (56)

 

1.30 (1.06–1.59)

Trend test

   

0.0051

 
  1. Bold indicated statistically significant.
  2. aχ2 test for the combined genotype distributions between the cases and controls.
  3. bAdjusted for age, sex, smoking and drinking status in logistic regression model.
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