Table 3 Stratified analysis of the FAS combined genotypes associated with CRC risk by demographic variables.
Variables | Case/control (n) | Combined genotypes (case/control) | P a | Adjusted OR (95% CI)b | |||
|---|---|---|---|---|---|---|---|
With rs2234767 GG/rs1800682 AA | Without rs2234767 GG/rs1800682 AA | ||||||
n | % | n | % | ||||
Total | 836/871 | 287/347 | 34/40 | 549/524 | 66/60 | 0.019 | 1.28 (1.05–1.56) |
Age (years) | |||||||
≤60 | 436/401 | 156/156 | 36/39 | 280/245 | 64/61 | 0.35 | 1.09 (0.82–1.45) |
>60 | 400/470 | 131/191 | 33/41 | 269/279 | 67/59 | 0.016 | 1.50 (1.13–1.99) |
Sex | |||||||
Male | 510/507 | 198/207 | 39/41 | 312/300 | 61/59 | 0.51 | 1.08 (0.84–1.39) |
Female | 326/364 | 89/140 | 27/38 | 237/224 | 73/62 | 0.0019 | 1.77 (1.26–2.47) |
Smoking status | |||||||
Never | 558/602 | 185/244 | 33/40 | 373/358 | 67/60 | 0.0093 | 1.39 (1.09–1.77) |
Ever | 278/269 | 102/103 | 37/38 | 176/166 | 63/62 | 0.70 | 1.08 (0.76–1.53) |
Drinking status | |||||||
Never | 610/655 | 207/264 | 34/40 | 403/391 | 66/60 | 0.019 | 1.33 (1.05–1.67) |
Ever | 226/216 | 80/83 | 35/38 | 146/133 | 65/62 | 0.51 | 1.16 (0.78–1.72) |
Family history of cancer | |||||||
No | 642/786 | 222/323 | 35/41 | 420/463 | 65/59 | 0.012 | 1.34 (1.08–1.67) |
Yes | 194/85 | 65/24 | 34/28 | 129/61 | 66/72 | 0.39 | 0.78 (0.44–1.37) |
