Table 4 Association between the FAS combined genotypes and progression of CRC.

From: FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin

Variables

Combined genotypes

P a

Adjusted OR (95% CI)b

With rs2234767 GG/rs1800682 AA

Without rs2234767 GG/rs1800682 AA

n

%

n

%

Controls (n = 871)

347

40

524

60

 

1.00 (reference)

Cases (n = 836)

      

Tumor grade

 Low

24

40

36

60

0.98

0.99 (0.58–1.70)

 Intermediate

219

34

427

66

0.018

1.30 (1.05–1.61)

 High

44

34

86

66

0.19

1.30 (0.88–1.91)

Dukes stage

 A + B

150

35

275

65

0.11

1.22 (0.96–1.55)

 C + D

137

33

274

67

0.025

1.33 (1.04–1.71)

  1. Bold indicated statistically significant.
  2. aχ2 test for the combined genotype distributions between the cases and controls.
  3. bAdjusted for age, sex, smoking and drinking status in logistic regression model.
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