Figure 2 | Scientific Reports

Figure 2

From: Comprehensive maternal serum proteomics identifies the cytoskeletal proteins as non-invasive biomarkers in prenatal diagnosis of congenital heart defects

Figure 2

Across the 5-Plex iTRAQ experiment a total of 47 differentially expressed serum proteins were identified.

(A) Venn diagram: the red region represents five proteins (TPM4, APOC1, SAA2, SAA4, PF4V1) that were differentially expressed in all of the CHD subtype groups, the yellow region represents six proteins (LMNA, MYH9, FLNA, ACTG1, HP, NRX2B) that were differentially expressed in three CHD subtype groups, the grey region represents 10 proteins that were differentially expressed in two CHD subtype groups and the white region represents 26 proteins that were differentially expressed in one CHD subtype group. (B) Classification of the differential expressed proteins in different categories based on their biological functions. TOF, tetralogy of Fallot; VSD, ventricular septal defects; PTA, persistent truncus arteriosus; MIX, a mixture of relatively rare types of CHDs; C, control. (C) Distribution of dysregulated proteins predicted as secreted (classically secreted and non-classically secreted) and non-secreted by SignalP and SecretomeP.

Back to article page