Figure 4
Fold-change induction of exon expression is more pronounced compared to gene expression.
(a,b) Cumulative distributions of fold changes in expression for significantly differentially expressed genes and exons after exposure to 0.1 Gy (a) and 1.0 Gy (b) of X-rays. p-values for the difference between distributions for genes and exons according to the Kolmogorov-Smirnov test were 0.195 and 0.000 for 0.1 Gy and 1.0 Gy, respectively. (c,d) Box plots depicting fold changes in expression for the same data as in (a,b). (c) Genes and exons upregulated at 0.1 Gy. (d) Genes and exons upregulated at 1.0 Gy. Centerlines show the median, boxes represent the range between the first and third quartiles and whiskers represent the highest and lowest values. ***p-value < 0.0001 (Two-tailed Mann-Whitney test).
