Table 2 Top 20 most important features selected by PAM and Random Forests models for the data at gene and exon level.

From: Radiation-induced alternative transcription and splicing events and their applicability to practical biodosimetry

 

Random Forests

PAM

Genes

Exons

Genes

Exons

1.

DDB2

ASCC3 exon 43 (8128473)

DDB2

DDB2 exon 4 (7939743)

2.

POLH

DDB2 exon 5 (7939744)

POLH

DDB2 exon 5 (7939744)

3.

AEN

XPC exon 15 (8085487)

MDM2

FDXR exon 8 (8018242)

4.

TNFRSF10B

TNFRSF10B exon 9 (8149735)

TNFRSF10B

DDB2 exon 8 (7939747)

5.

RPS27L

RPS27L exon 1 (7989499)

RPS27L

POLH exon 5 (8119864)

6.

FDXR

PCNA exon 2 (8064851)

AEN

AEN exon 3 (7985775)

7.

MDM2

XPC exon 2 (8085501)

PCNA

TNFRSF10B exon 9 (8149737)

8.

ZMAT3

ASCC3 exon 41 (8128476)

XPC

POLH exon 11 (8119870)

9.

XPC

ASCC3 exon 6 (8128513)

ASCC3

DDB2 exon 3 (7939742)

10.

C12orf5

POLH exon 11 (8119871)

ZMAT3

RPS27L exon 3 (7989497)

11.

EDA2R

ASCC3 exon 14 (8128504)

GADD45A

MDM2 exon 4 (7956994)

12.

NUP133

POLH exon 10 (8119869)

SESN1

DDB2 exon 9 (7939748)

13.

FBXO22

MDM2 exon 10 (7957001)

C12orf5

POLH exon 4 (8119863)

14.

GADD45A

POLH exon 1 (8119860)

EDA2R

MDM2 exon 7 (7956997)

15.

ZNF79

RPS27L exon 2 (7989498)

FDXR

DDB2 exon 6 (7939745)

16.

BAX

TNFRSF10B exon 7 (8149739)

CCNG1

POLH exon 10 (8119869)

17.

SESN1

ASCC3 exon 13 (8128505)

BAX

PCNA exon 3 (8064850)

18.

ACTA2

TNFRSF10B exon 5 (8149756)

PPM1D

TNFRSF10B exon 9 (8149735)

19.

ITGA2

PHPT1 exon 2 (8159444)

FAS

NDUFAF6 exon 2 (8147426)

20.

TMEM30A

ASCC3 exon 37 (8128481)

PAPPA-AS1

DDB2 exon 7 (7939746)

  1. Features are listed according to their internal weight (importance) in every model. The numbers in brackets in the Exons columns indicate corresponding Affymetrix Probe set IDs. Overlapping genes and exons are indicated in bold.