Table 2 Concentrations and related functions of the 4 selected plasma cytokines.

From: Exposure to Polycyclic Aromatic Hydrocarbons, Plasma Cytokines and Heart Rate Variability

Cytokines

Discovery stage

Validation stagec

Related functions

References

FCa

q-valueb (%)

BDNF

−3.62

<5.00

4.35 (1.75, 9.74)

Plays a protective role by inducing angiogenesis; induction of methylation changes in response to PAHs

30,34

ALCAM

2.74

<5.00

106.22 (80.64, 134.09)

Regulation of endothelial cell function; induce inflammation by recruitment of leukocytes

39,44

CRP

2.01

<5.00

1.14 (0.45, 2.20)

Induction of proinflammatory effects via NF-κB activation;associated with cardiovascular risk factors in response to particulate matter

12,45

MSP

2.31

5.00

93.52 (56.49, 153.49)

Plays a dual role in regulating inflammation

46

  1. aNegative values indicate that cytokine concentration was lower in the exposed group; positive values indicate that cytokine concentration was higher in the exposed group.
  2. bA minimal false discovery rate (q-value) for significance.
  3. cValues are median (25th percentile, 75th percentile). The units of BDNF, ALCAM and MSP are ng/mL; the unit of CRP is mg/L.
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