Table 2 Multivariate analyses of alcohol intake variables for all 1923 male nasopharyngeal carcinoma patients and patients stratified by age/smoking status.

From: Alcohol drinking as an unfavorable prognostic factor for male patients with nasopharyngeal carcinoma

Alcohol intake variables

OS

LRFS

HR (95% CI)

P-value

HR (95% CI)

P-value

All patients

 Status of alcohol intake (vs. non-drinker)

 

0.037

1.15 (0.83–2.32)

0.025

 Former drinker

1.19 (0.77–1.79)

0.297

1.15 (0.83–2.32)

0.382

 Current drinker

1.24 (1.01–1.53)

0.043

1.30 (1.06–1.60)

0.013

 Intensity of alcohol intake (≥14 vs. <14 drinks/week)

1.47 (1.12–1.92)

0.006

1.39 (1.05–1.84)

0.023

 Duration effect of alcohol intake (≥20 vs. <20 years)

1.30 (1.02–1.66)

0.037

1.36 (1.07–1.77)

0.013

Patients with an age <47 years

 Status of alcohol intake (vs. non-drinker)

 

0.624

 

0.326

 Former drinker

0.57 (0.80–4.10)

0.579

0.55 (0.08–3.96)

0.553

 Current drinker

1.15 (0.81–1.64)

0.442

1.27 (0.90–1.78)

0.179

 Intensity of alcohol intake (≥14 vs. <14 drinks/week)

0.99 (0.44–2.22)

0.978

0.95 (0.42–2.12)

0.897

 Duration of alcohol intake (≥20 vs. <20 years)

1.33 (0.76–2.31)

0.314

1.46 (0.86–2.46)

0.161

Patients with an age ≥47 years

 Status of alcohol intake (vs. non-drinker)

 

0.023

 

0.029

 Former drinker

1.27 (0.98–1.64)

0.059

1.65 (0.99–2.77)

0.055

 Current drinker

1.76 (1.07–2.89)

0.026

1.31 (1.02–1.69)

0.039

 Intensity of alcohol intake (≥14 vs. <14 drinks/week)

1.61 (1.20–2.15)

0.001

1.53 (1.13–2.08)

0.006

 Duration of alcohol intake (≥20 vs. <20 years)

1.31 (1.00–1.70)

0.047

1.34 (1.02–1.76)

0.039

Non-smokers

 Status of alcohol intake (vs. non-drinker)

 

0.344

 

0.063

 Former drinker

0.96 (0.13–6.88)

0.965

1.15 (0.16–8.27)

0.891

 Current drinker

1.55 (0.86–2.78)

0.144

1.93 (1.12–3.35)

0.019

 Intensity of alcohol intake (≥14 vs. <14 drinks/week)

1.22 (0.42–3.55)

0.715

1.43 (0.49–4.20)

0.514

 Duration of alcohol intake (≥20 vs. <20 years)

1.95 (0.95–3.98

0.069

2.63 (1.33–5.19)

0.005

Smokers

 Status of alcohol intake (vs. non-drinker)

 

0.058

 

0.079

 Former drinker

1.58 (0.96–2.60)

0.073

1.40 (0.84–2.34)

0.198

 Current drinker

1.54 (1.01–2.42)

0.049

1.26 (1.01–1.57)

0.044

 Intensity of alcohol intake (≥14 vs. <14 drinks/week)

1.51 (1.14–2.01)

0.005

1.42 (1.20–1.84)

0.020

 Duration of alcohol intake (≥20 vs. <20 years)

1.28 (0.99–1.65)

0.061

1.31 (1.01–1.69)

0.041

  1. Abbreviation: OS, overall survival; LRFS, locoregional recurrence-free survival; CRT, chemoradiotherapy; RT, radiotherapy; HR, hazard ratio; 95% CI, 95% confidence interval; NS, non-significant.
  2. The following parameters were included in the multivariate analysis using Cox proportional hazards model by enter method: age (≥47 vs. <47 years), T classification (T3–4 vs. T1–2), N classification (N0–1 vs. N2–3), treatment (CRT vs. RT), smoking status (smoker vs. non-smoker), smoking index (≥15 vs. <15 pack-years) and status (former/current drinker vs. non-drinker)/intensity (≥14 vs. <14 drinks/week)/duration (≥20 vs. <20 years) of alcohol intake.
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