Figure 3 | Scientific Reports

Figure 3

From: Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis

Figure 3

AZD3463 inhibits the downstream signaling pathway of ALK, PI3K/AKT/mTOR and induces apoptosis and autophagy in NB cells.

IMR-32, NGP, SH-SY5Y and SK-N-AS cells were treated with 10 μM of AZD3463 for various time points (0–4 hrs), subjected to SDS-PAGE and then immunoblotted with PARP, p-Akt, Akt, p-S6, S6, Caspase 3, LC3A/B and β-Actin antibodies.

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