Figure 1
From: Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
Correlation of SQLE copy number and gene expression is highest in breast and ovarian cancers.
All cancer histotypes with at least 100 cases collected by the TCGA were assessed for the presence of SQLE copy number gains and losses (blue and orange respectively, left bar chart (A) and log2 ratios were correlated with normalized SQLE gene expression using the Spearman’s correlation coefficient (ρ value on the x-axis, decreasing from highest to lowest, right bar chart (A). SQLE copy number/gene expression correlation was invariably higher than for MYC, which is physically closely located on chromosome 8q, in both breast (topmost panels, (B) and ovarian cancer (topmost panels, (C). Moreover, SQLE and MYC gene expression values were not correlated in those cancer types (bottom left B and C), whereas copy number values were almost identical due to the aforementioned chromosomal proximity (bottom right B and C). Topmost y-axes and bottom left x- and y-axes C and D: normalized log2 gene expression intensity. Bottom right x- and y-axes C and D: log2 ratios for copy number values. Full definitions of the TCGA acronyms can be found at https://tcga-data.nci.nih.gov/tcga.
