Figure 3
From: Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
SQLE high expression is independently associated with unfavorable prognosis in breast cancer.
Patients affected by tumors bearing chromosome 8q24.13-q24.21 (the region encompassing SQLE and MYC) gains or amplifications are characterized by poorer overall survival (OS), (A). However, whilst MYC expression levels have per se no prognostic value (B), SQLE overexpression is not only associated with worse OS by univariable analysis (C), but also maintains its independent prognostic value in a Cox proportional hazard model, including all classical clinical and pathological parameters, as shown in the forest plot depicted in panel (D) (HRs represented by black triangles and 95% CIs showed as horizontal black lines). Data are from the METABRIC set. P values in the bottom left area of Kaplan-Meier curves are obtained using the log-rank test. Panel D abbreviations: Intm. = Intermediate, y.o. = years old, NPLN = number of positive lymph nodes.
