Table 4 Breast cancer cell line SQLE characteristics and experimental results.

From: Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer

Cell line

Mean ploidy

CNA / focalB

GEC ± 95% CI

IC50[μM]D ± 95% CI

DTE-hours (scrambledF) ± 95% CI

DT - hours (siSQLEG)

MCF-7

3.57

9/yes

0.94 ± 0.03

32.1 ± 3.1

61.7 ± 3.7

90.4 ± 5.6

Hs 578T

2.45

5/no

2.02 ± 0.14

52.2 ± 4.0

146.8 ± 5.8

170.3 ± 5.5

SK-BR-3

3.85

13/yes

0.92 ± 0.21

84.9 ± 6.8

n.p.H

n.p.

MDA-MB-468

2.79

4/no

1.28 ± 0.02

115.4 ± 10.3

n.p.

n.p.

T-47D

2.62

4/no

0.47 ± 0.02

140.8 ± 18.4

55.3 ± 1.3

73.5 ± 1.2

MDA-MB-231

2.64

1/yes

0.05 ± 0.01

220.9 ± 8.8

48.3 ± 4.2

48.7 ± 2.0

  1. ACopy number. BDefined thus when aberration encompasses less than 20% of chromosomal arm. CGene expression. DTerbinafine micromolar concentration inhibiting cellular growth by 50%. EDoubling time. FNegative siRNA control. GSQLE-targeting siRNA. HNot performed.
Back to article page