Figure 2
From: DNMT3L enables accumulation and inheritance of epimutations in transgenic Drosophila
Ectopic DNMT3L expression causes melanotic tumors in transgenic flies from the fifth generation.
Images of 3rd instar larvae from DNMT3L transgenic flies in the absence and presence of GAL4 drivers. Melanotic tumors were observed in DNMT3L transgenic flies in the larval stage after maintaining the flies for five generations. The melanotic tumors are marked by arrows. The location of the melanotic tumors varied in different larvae. UAS-3L - transgenic DNMT3L flies without any GAL4 driver. Tub-3L, Actin-3L, da-3L - transgenic DNMT3L flies with Tubulin, Actin or daughterless GAL4 driver respectively.
