Figure 3 | Scientific Reports

Figure 3

From: Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

Figure 3

TubA (25 mg/kg) ameliorated neuronal cell death in the ischemic cortex on Day 3 after ischemia.

As detected by NeuN staining, middle cerebral artery occlusion (MCAO) induced severe neuronal cell death (B) in the ischemic cortex, compared with sham control (A). TubA, given immediately (C) or at 24 hours (D) after MCAO significantly increased neuron survival. (E) Quantification of number of neurons per mm2 in the ischemic cortex. ###P < 0.001 compared with sham control; *P < 0.05, ***P < 0.001 compared with MCAO group; n = 6 per group.

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