Figure 4
Rapamycin treatment decreases α-syn accumulation and restores the autophagy-lysosome pathway in the substantia nigra of PD mouse.
(a) Immunoblot and the optical density of α-syn in the mouse SNpc in each group after rapamycin treatment for 12 days. (b) The overall rod performance (ORP) scores of mice in each group (n = 8). (c) Immunoblot levels of p-mTOR, p-P70S6K and ULK1 in the mouse SNpc in each group after acupuncture and rapamycin treatment. (d–f) The optical density of p-mTOR, p-P70S6K and ULK1 in the mouse SNpc in each group. In all panels, *P < 0.05, **P < 0.01 compared with SG. #P < 0.05, ##P < 0.01 compared with PG.
