Figure 6

iPSC microvesicles fuse to target cells in vitro.

(A) iPSC MV co-cultured GFP⁺ RPCs remain viable expressing GFP ubiquitously throughout the cytoplasm and robust branching morphology. (B) Dendritic processes and cell-to cell contacts visible using phase contrast. (C) MVs isolated from iPSCs labeled with the red fluorescent lipophilic dye PKH26fuse to GFP+RPCs. (D) Overlay (A–C). scale 10 μm.