Figure 2
From: Essential role of proteasomes in maintaining self-renewal in neural progenitor cells
Down-regulation of proteasomes and their activity in aged NPCs.
(A,B) Western-blotting analysis showed that the protein expressions of 20S proteasome and the subunit PSMB5 in the SVZ were decreased in P90 and P540 mice. (C) The proteasomal activity in the SVZ (or the VZ/SVZ at E14) was measured in mice at the time points specified. (D) The proteasomal activities in NPCs from P90 and P540 mice were significantly lower than that in E14 or P0 mice. (E) qPCR analysis on the expression of 20S proteasome subunits in NPCs isolated from E14, P0, P90 and P540 mice. *p < 0.05 and **p < 0.01 vs. E14, #p < 0.05 and ##p < 0.01 vs. P0.
