Table 1 Differentially expressed proteins potentially related to synergistic mechanism.

narG

Nitrate reductase, alpha subunit

(−)73.4 (Repression)

(−)6.4

Membrane

Nitrogen metabolism

adh

Alcohol dehydrogenase

(−)49.1 (Repression)

(−)13.1

CytopPlasmic

Tyrosine metabolism; Fatty acid metabolism; Glycolysis/Gluconeogenesis;

HMPREF0772_10696

LPXTG-motif cell wall anchor domain protein

(−)44.1

(−)9.1

Cell wall

nirB

Assimilatory nitrite reductase (NAD(P)H) large subunit (EC 1.7.1.4)

(−)35.8

(−)6.0

Cytoplasmic

ebh SAR1447

Extracellular matrix-binding protein ebh (ECM-binding protein homolog)

(−)27.7 (Repression)

(−)4.8

Cell wall

pfl

Formate C-acetyltransferase (EC 2.3.1.54)

(−)27.5

(−)5.3

Cytoplasmic

Butanoate metabolism; Propanoate metabolism; Pyruvate metabolism

sdrD

Serine-aspartate repeat-containing protein D

(−)24.3

—

Cell wall

sceD SaurJH9_2132

Transglycosylase domain protein, probable transglycosylase SceD

(−)22.9 (Repression)

(−)12.5 (Repression)

Extracellular

narH

Respiratory nitrate reductase β subunit

(−)21 (Repression)

(−)7.5

CytoplasmicMembrane

Nitrogen metabolism

SaurJH9_1471

Uncharacterized protein

(−)15.2

(−)5.2

Unknown

ldh1

L-lactate dehydrogenase 1 (L-LDH 1) (EC 1.1.1.27)

(−)11.9

(−)3.5

Cytoplasmic

Cysteine and methionine metabolism; Glycolysis/Gluconeogenesis; Propanoate metabolism; Pyruvate metabolism

sle

N-acetylmuramoyl-L-alanine amidase Sle1 (EC 3.5.1.28)

(−)7.3

(−)3.5

Cell wall

SaurJH9_2406

Pyridoxamine 5'-phosphate oxidase-related, FMN-binding

(−)6.2

—

Unknown

SaurJH9_0817

Cold-shock DNA-binding protein family

(−)5.1

(−)2.9

Cytoplasmic

blaZ

β-Lactamase (EC 3.5.2.6)

(+)4 (Induction)

(+)16.8 (Induction)

Cell wall

β-Lactam resistance

uvrB

UvrABC system protein B (Protein UvrB) (Excinuclease ABC subunit B)

(+)5.3 (Induction)

ND

Cytoplasmic

Nucleotide excision repair

SaurJH9_2077

PfkB domain protein

(+)5.4

ND

Cytoplasmic

Amino sugar and nucleotide sugar metabolism; Fructose and mannose metabolism; Starch and sucrose metabolism

SaurJH9_2631

AMP-dependent synthetase and ligase

(+)5.5

—

Cytoplasmic

Carbon fixation pathways in prokaryotes; Glycolysis/Gluconeogenesis; Propanoate metabolism; Pyruvate metabolism

lysA

Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20)

(+)5.5 (Induction)

—

Cytoplasmic

Lysine biosynthesis

SaurJH9_1347

Uncharacterized protein

(+)5.7

—

Cytoplasmic

SaurJH9_1452

Uncharacterized protein-like protein

(+)6.1 (Induction)

(+)3.8 (Induction)

Cytoplasmic

pycA

Pyruvate carboxylase (EC 6.4.1.1)

(+)6.7

ND

Cytoplasmic

Citrate cycle (TCA cycle); Carbon fixation pathways in prokaryotes; Pyruvate metabolism

nadE

NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5)

(+)8.4

(+)5.5 (Induction)

Cytoplasmic

Nicotinate and nicotinamide metabolism

msrA

Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)

(+)8.5

—

Extracellular

prsA

Foldase protein PrsA (EC 5.2.1.8)

(+)9.6

(+)4.3

CytoplasmicMembrane

purH

Bifunctional purine biosynthesis protein PurH

(+)9.8

ND

Cytoplasmic

One carbon pool by folate; Purine metabolism

mecA

Penicillin binding protein 2a (EC 2.4.1.129)

(+)11.8

(+)42.0

CytoplasmicMembrane

β-Lactam resistance

SaurJH9_1988

ABC transporter related

(+)12.2 (Induction)

ND

CytoplasmicMembrane

ABC transporters

miaB

(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB (EC 2.-.-.-)

(+)12.8

ND

Cytoplasmic

mnaA

UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14)

(+)13.8

ND

Cytoplasmic

Amino sugar and nucleotide sugar metabolism

ureG

Urease accessory protein UreG

(+)13.9 (Induction)

ND

Cytoplasmic

SaurJH9_0016

Primary replicative DNA helicase (EC 3.6.1.-)

(+)14.7

ND

Cytoplasmic

DNA replication; Alanine, aspartate and glutamate metabolism; Purine metabolism