Table 4 Association results of 3 tested SNPs with obesity-related traits in the replication sample, GIANT and DIAGRAM Consortiums.

From: Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population

   

BMI

Fat Mass

WHRadjBMI

GIANTb

 

SNP

A1/A2a

MAF

β

P

βmeta

P meta

β

P

βmeta

P meta

β

P

βmeta

P meta

WHRadjBMI

HIPadjBMI

DIAGRAMc

rs167428

C/T

0.110

−0.385

0.053

−0.374

2.48 × 10−3

−0.684

0.044

−0.888

3.46 × 10−5

−3.34 × 10−3

0.402

−3.90 × 10−3

0.111

0.44

0.15

0.29

rs308442

A/T

0.196

−0.083

0.595

−0.156

0.111

−0.099

0.710

−0.517

2.38 × 10−3

−2.57 × 10−3

0.414

−1.90 × 10−3

0.339

0.19

6.8 × 10−2

0.18

rs1048201

T/C

0.442

−0.261

0.040

0.005

0.951

−0.481

0.044

0.139

0.314

−1.56 × 10−3

0.533

−1.00 × 10−3

0.529

0.037

3.8 × 10−4

0.01

  1. MAF, minor allele frequency. β is calculated with respect to the minor allele. Meta-analysis was performed with effect size estimates weighted by the inverse of the corresponding standard errors (βmeta and Pmeta).
  2. aA1 represents the minor allele.
  3. bWHRadjBMI and HIPadjBMI association P values are from the GIANT Consortium of 210,088 European individuals.
  4. cP values are from the DIAGRAM Consortium of 12,171 T2D cases and 56,862 controls of European descent.