Figure 2
Influence of cell–cell adhesion energy (Jcc) on invasion efficiency.
(A) Temporal patterns of invasion of a group of cells enmeshed in a fibrillar ECM network for different levels of cell–cell adhesion. Upper Panel: High cell–cell adhesion (Jcc=1). Middle Panel: Medium cell–cell adhesion (Jcc = 16). Lower Panel: Low cell–cell adhesion (Jcc = 40). Model components: Blue pixels represent fluid, yellow pixels represent ECM fibres and coloured boxes represent cells. (B) Quantification of cell migration pattern with number of clusters and average size of cell cluster after 1800 MCS. (C) percentage ECM degradation for different values of Jcc. (D) Temporal profile of total number of MMP molecules present in the lattice for varying values of Jcc. (E) Total distance moved by cells (
) and net cell translocation (
) for different values of Jcc. Inset shows representative trajectory of a single cell. Error bars: ±standard error of mean (SEM).
