Figure 5 | Scientific Reports

Figure 5

From: Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration

Figure 5

LIF partially reversed the inhibitory effects of IDO knockdown on trophoblast cell proliferation and migration.

(A) After treatment with LIF, pSTAT3 expression in IDO knockdown HTR-8/SVneo cells was obviously increased. (B) LIF completely reversed the inhibitory effect on cell proliferation in IDO knockdown HTR-8/SVneo cells. (C,D) LIF partially reversed the inhibitory effect on migration in IDO knockdown HTR-8/SVneo cells (n = 3; Student’s t-test; **p < 0.01, ***p < 0.001).

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