Figure 6 | Scientific Reports

Figure 6

From: Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration

Figure 6

STAT3 overexpression reversed the inhibitory effects of IDO knockdown on trophoblast cell proliferation and migration.

(A) Western blot analysis of pSTAT3 in STAT3 overexpressing shIDO2 HTR-8/SVneo cells. Total STAT3 was used as an internal control. (B) Statistical analysis of protein expression in A (n = 3; Student’s t-test; **p < 0.01). (C) Proliferation ability of STAT3-overexpressing shIDO2 HTR-8/SVneo cells was higher than the control group (n = 3; Student’s t-test; **p < 0.01). (D,E) Migration ability of STAT3-overexpressing shIDO2 HTR-8/SVneo cells was higher than the control group (n = 3; Student’s t-test; ***p < 0.001).

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