Figure 7

IDO promotes cell proliferation and migration via the STAT3 signaling pathway.

(A) Western blot analysis of IDO in IDO-overexpressing HTR-8/SVneo cells. GAPDH was used as an internal control. (B) Statistical analysis of protein expression in A (n = 3; Student’s t-test; **p < 0.01). (C) Proliferation ability of IDO-overexpressing HTR-8/SVneo cells treated with vehicle or AG490 (n = 3; Student’s t-test; *p < 0.05, **p < 0.01, ***p < 0.001 in comparison to the control group treated with vehicle, ^##p < 0.01, ^###p < 0.001 in comparison to the IDO-overexpressing group treated with vehicle) (D,E) Migration ability of IDO-overexpressing HTR-8/SVneo cells treated with vehicle or AG490 (n = 3; Student’s t-test; **p < 0.01, ***p < 0.001 in comparison to the control group treated with vehicle, ^###p < 0.001 in comparison to the IDO-overexpressing group treated with vehicle).