Figure 8 | Scientific Reports

Figure 8

From: Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration

Figure 8

pSTAT3 and MMP9 expression in IDO-overexpressing HTR-8/SVneo cells.

(A) Western blot analysis of pSTAT3 in IDO-overexpressing HTR-8/SVneo cells treated with vehicle or AG490. Total STAT3 was used as an internal control. (B) Statistical analysis of protein expression in A (n = 3; Student’s t-test; **p < 0.01 in comparison to the control group treated with vehicle, ##p < 0.01 in comparison to the IDO-overexpressing group treated with vehicle). (C) Western blot analysis of MMP9 in IDO-overexpressing HTR-8/SVneo cells treated with vehicle or AG490. GAPDH was used as an internal control (D) Statistical analysis of protein expression in A (n = 3; Student’s t-test; *p < 0.05 in comparison to the control group treated with vehicle, ##p < 0.01 in comparison to the IDO-overexpressing group treated with vehicle).

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