Table 1 Main characteristics of all epidemiological studies on sperm quality and EDCs included in the meta-analysis.
Compounds | Study design | N in Analysis | Specimen | Concentration | Sperm quality | Results | Author (year) |
|---|---|---|---|---|---|---|---|
MBP | Cross-sectional | 232 general men | urine | 22.9 μg/g (CR adjusted) | Weak association with low sperm concentration | Sperm concentration (OR = 1.97,95%CI: 0.95,4.08) | Han, X et al. (2014)34 |
MBP | Cross-sectional | 150 individuals recruited from reproductive institute | urine | 25.7 ng/mL(CR adjusted) | ↓Sperm concentration | Sperm concentration (OR = 6.8,95%CI: 0.6,75.3,p = 0.05) | Liu et al. (2012)33 |
MEP | Pilot | 45 male partners of subfertile couples | urine | 121.9 ng/mL | ↓ Sperm concentration | (OR = 6.5,95% CI: 1.0–43.6, p < 0.05) | Wirth et al. (2008)29 |
MBzP | Pilot | 45 male partners of subfertile couples | urine | 26.9 ng/mL | No association | (OR = 1.4, 95% CI: 0.3, 6.3) | |
MMP | Pilot | 45 male partners of subfertile couples | urine | 1.1 ng/mL | No association | (OR = 0.8, 95% CI: 0.2, 3.8) | |
MCPP | Pilot | 45 male partners of subfertile couples | urine | 2.5 ng/mL | ↓ Morphology | (OR = 7.6, 95% CI: 1.7–33.3) | |
MBP | Cross-sectional | 463 male partners of subfertile couple | urine | 17.3 ng/mL | ↓ Sperm concentration, motility | Sperm concentration (OR = 3.3,95%CI: 1.2,8.5) Sperm motility (OR = 1.8,95%CI: 1.1,3.2) | Hauser et al. (2006)21 |
MBP | Cross-sectional | 168 male partners of subfertile couples | urine | 16.1 ng/mL | ↓ Sperm concentration, motility, morphology | Sperm concentration (OR = 2.7,95%CI: 0.8,7.2) Sperm motility (OR = 2.4,95%CI: 1.1,5.0) Sperm morphology (OR = 1.7,95%CI: 0.8,3.9) | |
MEHP | Cross-sectional | 168 male partners of subfertile couples | urine | 7.6 ng/mL | No association | Sperm concentration (OR = 1.0,95%CI: 0.3,2.9) Sperm motility (OR = 1.4,95%CI: 0.7.2.9) Sperm morphology (OR = 1.2,95%CI: 0.5,2.8) | Duty et al. (2003a)22 |
MMP | Cross-sectional | 168 male partners of subfertile couples | urine | 7.5 ng/mL | ↓ Morphology | Sperm concentration (OR = 1.7,95%CI: 0.4,7.9) Sperm motility (OR = 1.1,95%CI: 0.4,3.3) Sperm morphology (OR = 3.2,95%CI: 0.8,12.2) | |
PCB-153 | Cross-sectional | 303 male partners of subfertile couple | serum | 43 ng/g lipids | ↓ Motility | OR = 2.68 (95%CI: 1.44–4.99) | Hauser et al. (2005)30 |
ΣPCB congeners | Cross-sectional | 303 male partners of subfertile couple | serum | 223 ng/g lipids | ↓ Motility | OR = 2.80 (95%CI:1.50–5.23) | |
PCB-138 | Cross-sectional | 212 male partners of subfertile couples | serum | 33.6 ng/g lipids | ↓ Morphology ↓ Motility | Sperm motility (OR = 1.68,95%CI: 0.82,3.42,p = 0.03) Sperm morphology (OR = 1.36,95%CI: 0.57,3.22,p = 0.04) | Hauser et al. (2003)16 |
DDE/DDT | Cross-sectional | 336 male partners of couples presenting to infertility clinics | serum | 0.05 μg/g lipid (p,p′-DDT), 0.29 μg/g lipid (p,p′-DDE) | Low sperm count, motility and abnormal morphology | Sperm count (OR = 2.53; 95% CI = 1.0–6.31), Motility (OR = 2.91; 95% CI = 1.27–6.66), Morphology (OR = 3.23; 95% CI = 1.51–6.95) | Messaros et al. (2009)31 |
Metolachlor | Case-control | 25 cases and 25 controls | urine | 0.48 μg/g (CR adjusted) | No association | OR = 3.3 (95% CI:0.8–14.5) | Swan et al. (2006)32 |
2,4-D | Case-control | 25 cases and 25 controls | urine | 0.56 μg/g (CR adjusted) | No association | OR = 0.8 (95% CI:0.2–3.0) |
