Table 2 Hemodynamic and echocardiographic parameters in control and Tg-KLK8 rats

From: Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy

 

6-week old Control Tg-KLK8

12-week old Control Tg-KLK8

N

6 6

7 7

LVW/BW (mg/g)

2.41 ± 0.05 3.02 ± 0.09**

2.00 ± 0.09 2.44 ± 0.12#

HW/BW (mg/g)

3.25 ± 0.04 3.75 ± 0.20*

2.91 ± 0.09 3.29 ± 0.12#

LVAWs (mm)

2.46 ± 0.13 3.27 ± 0.14**

2.63 ± 0.09 3.25 ± 0.2#

LVAWd (mm)

1.41 ± 0.08 1.84 ± 0.11**

1.40 ± 0.08 1.93 ± 0.11##

LVPWs (mm)

2.64 ± 0.15 3.22 ± 0.14*

2.91 ± 0.14 3.48 ± 0.18#

LVPWd (mm)

1.61 ± 0.08 1.87 ± 0.20

1.41 ± 0.10 1.87 ± 0.15#

LVIDs (mm)

1.90 ± 0.35 1.75 ± 0.10

2.08 ± 0.19 1.94 ± 0.12

LVIDd (mm)

5.89 ± 0.32 4.70 ± 0.08**

5.54 ± 0.11 4.95 ± 0.18#

%EF

78.14 ± 3.62 89.83 ± 3.09*

88.32 ± 1.57 78.19 ± 3.29#

%FS

48.37 ± 3.71 62.34 ± 4.17*

59.46 ± 2.38 48.17 ± 3.16#

Heart rate, bpm

407 ± 21 437 ± 26

387 ± 11 373 ± 14

dP/dtmax, mmHg/s

5260 ± 199 6114 ± 239*

6201 ± 592 3782 ± 342##

dP/dtmin, mmHg/s

4171 ± 300 5496 ± 306*

5542 ± 538 3492 ± 364##

  1. *p < 0.05, **p < 0.01 vs 6-week old littermate control rats; #p < 0.05, ##p < 0.01 vs 12-week old littermate control rats. bpm, beats per minute; dP/dtmax, maximum first derivative of pressure; dP/dtmin, minimum first derivative of pressure; LVW, left ventricle weight; BW, body weight; HW, heart weight; LVAWs, left-ventricular end-systolic anterior wall thickness; LVAWd left-ventricular end-diastolic anterior wall thickness; LVPWs, left-ventricular end-systolic posterior wall thickness; LVPWd, left-ventricular end-diastolic posterior wall thickness; LVIDs, left-ventricular end-systolic internal diameter; LVIDd, left-ventricular end-diastolic internal diameter; EF, ejection fraction; FS, fractional shortening.
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