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Figure 1

From: A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, attenuates collagen-induced arthritis and inhibits TLR4 signalling in rats

Figure 1

Effects of RL on disease progression in CIA rats.

Male Wistar rats were immunized on day 0 and day 7 with bovine type II collagen for CIA or with vehicle. CIA rats were intragastrically (i.g.) given vehicle (saline), indomethacin (Indo), low dose of RL (RL-L), middle dose of RL (RL-M) or high dose of RL (RL-H) (n = 8 for each group) daily from days 14 to 56. (A) Average volumes of hind paws. (B) Mean arthritic score. (C) Representative photographs showing the gross features of hind paws at day 57. (D) Average daily food intake during the experimental period. (E) Changes in body weight over the experimental period. Values are the mean ± SEM (n = 8). *P < 0.05, **P < 0.01 compared with the immunized control (saline).

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