Figure 4 | Scientific Reports

Figure 4

From: A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, attenuates collagen-induced arthritis and inhibits TLR4 signalling in rats

Figure 4

Effects of RL on TLR4 signalling in joint tissues of CIA rats.

(A) Representative western blots showing the protein expression of TLR4, phospho-TAK1, phospho-NF-κB p65, phospho-c-Jun, phospho-IRF3 and β-actin (as loading control) in joint tissues. (B) Relative intensity values from band densitometry. The values are the mean ± SEM of the band density normalized to the loading control in relation to mean value of untreated control (control) normalized to the loading control (n = 8). (C) Levels of cytokines from joint tissue lysates determined by Milliplex MAP Rat Cytokine/Chemokine Panel or ELISA at the end of the experiment. Values are the mean ± SEM (n = 8). *P < 0.05, **P < 0.01 compared with the immunized control (saline).

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