Table 4 Cytotoxic Evaluation of Compounds 1–5, 7–11 and 13–14a.

From: Cytotoxic Rocaglate Derivatives from Leaves of Aglaia perviridis

Compound

HepG2 b

HL-60 c

MCF-7 e

HT-29 d

1

0.014

0.009

0.009

0.008

2

>50.00

>50.00

>50.00

>50.00

3

>50.00

>50.00

>50.00

>50.00

4

>50.00

>50.00

>50.00

>50.00

5

10.9

2.2

8.5

1.4

7

>50.00

>50.00

>50.00

>50.00

8

>50.00

>50.00

>50.00

>50.00

9

27.7

29.4

36.0

23.1

10

0.016

0.013

0.008

0.008

11

0.006

0.007

0.008

0.008

13

23.0

19.5

31.1

16.3

14

>50.00

>50.00

>50.00

>50.00

Taxolf

   

0.002

cis-platinumg

8.2

2.5

6.4

 
  1. aResults are expressed as IC50 values (μM).
  2. b,c,dCompounds 24, 78, 14, were inactive against HepG2 cells (IC50 > 50 μM).
  3. fUsed as a positive control for the cytotoxicity assay against HT-29 cells.
  4. gUsed as a positive control for the cytotoxicity assay against HepG2, HL-60 and MCF-7 cells.