Figure 1
From: Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca2+ release channel
Developmental retardation and disorganization of skeletal muscle of dysp mice.
(a) Heterozygous controls (het, left) and dysp (right) littermates at day E18.5 from three different litters (I, II and III). The dysp littermates display abnormal spine curvature, small limbs and enlarged necks. (b) At E18.5, the distal hind limb of control littermates contains well-developed muscle fibres (*) organized in fascicles, which are surrounded by an epimysial fascia (arrows). (c) In contrast, at E18.5 the distal hind limb of dysp mice contains only immature small fibers (arrows) in a scattered distribution, lacking a fascia (b,c): H&E staining; original magnification × 50 (a,b); × 200 (insets I); × 400 (insets II).
