Figure 1 | Scientific Reports

Figure 1

From: Digital detection of endonuclease mediated gene disruption in the HIV provirus

Figure 1

Cleavage of HIV pol by an engineered megaTAL.

(A) Location of the megaTAL cleavage site (S20, red triangle) within the HIV provirus. (B) Tal effector (TALE) and meganuclesase domains for the HIV pol-specific 6.5 or 7.5 RVD repeat containing megaTALs alongside their HIV pol target sequences. TALE binding (red), S20 meganuclease binding (blue) and S20 meganuclease cleavage (underlined) sites are shown. NTD – N-terminal domain; CTD – C-terminal domain.

Back to article page