Figure 5: MMP1a plays a critical role in the donor-derived exosome-induced allograft tolerance. | Scientific Reports

Figure 5: MMP1a plays a critical role in the donor-derived exosome-induced allograft tolerance.

From: Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart

Figure 5

Similar to Fig. 2, the recipient mice of heart allograft were treated with the exosomes (or non-donor-derived exosomes; #) and anti-MMP1a (0.25 mg/mouse) or MMP1a (0.1 mg/mouse) on the day of surgery. (A) the heart histology image shows infiltration of inflammatory cells. (B–D) the histograms show the frequency of IL-4+ T cells (B), IFN-γ+ T cells and proliferating CD4+ T cells (D). Each group consists of 12 mice. Samples from 4 mice were pooled as one sample.

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