Table 1 Characteristics of the studied groups and results of muscle energy metabolism measurements via static 31P-MRS, saturation transfer and dynamic experiments.

From: Skeletal muscle alkaline Pi pool is decreased in overweight-to-obese sedentary subjects and relates to mitochondrial capacity and phosphodiester content

Variable

Overweight Obese/Sedentary

Lean/Active

N (female)

14 (5)°

15 (5)

Age (years)

34.6 ± 7.1

29.3 ± 5.5

BMI (kg.m−2)

30.4 ± 2.3

23.1 ± 2.6*

Body fat (%)

35.2 ± 7.1

18.3 ± 6.1*

LBM (kg)

62.4 ± 10.9

63.0 ± 15.6

VO2max (mL.min−1.kg−1)

36.8 ± 5.3

45.9 ± 3.1*

Steps per 24 hours

6052 ± 1166

11093 ± 4074*

static MRS

 [PDE] (mM)

4.21 ± 1.12

2.82 ± 1.00*

 [GPC] (mM)

3.95 ± 1.04

2.47 ± 0.98*

 [GPE] (mM)

0.26 ± 0.27

0.23 ± 0.17

 [Pi2] (mM)

0.18 ± 0.07

0.28 ± 0.06*

 Pi2/Pi

0.05 ± 0.02

0.08 ± 0.02*

 pHrest

7.06 ± 0.04

7.05 ± 0.03

 [ADP]rest(μM)

10.1 ± 0.9

9.8 ± 0.6

ST

 kATP (s−1)

0.07 ± 0.02

0.08 ± 0.01

 FATP (mM.s−1)

0.25 ± 0.06

0.31 ± 0.04†

 kCK (s−1)

0.27 ± 0.05

0.25 ± 0.05

 FCK (mM.s−1)

9.26 ± 2.36

8.66 ± 2.40

Dynamic

 PCr drop (% signal)

38.4 ± 19.4

40.4 ± 13.9

 τPCr (s)

40.9 ± 14.0

42.6 ± 15.8

 VPCr (mM.s−1)

0.29 ± 0.10

0.32 ± 0.07

 Qmax (mM.s−1)

0.50 ± 0.08

0.58 ± 0.07†

 pHend_exercise

6.97 ± 0.14

6.90 ± 0.16

 [ADP]end exercise(μM)

47.8 ± 32.0

40.9 ± 15.5

  1. Data are given as mean ± standard deviation. °For one volunteer from the overweight-to-obese sedentary group, only dynamic experiment data are available. Significant differences (unpaired t-test) between the groups are depicted as follows: *p < 0.01; †p < 0.05.
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