Figure 7
(A) Phe increased expression of DNMT1, DNMT3a and DNMT3b in rat hearts. Based on the results of Western blotting, we found that various doses of Phe were capable of increasing the expression of DNMT1, DNMT3a and DNMT3b in rat hearts. Intensities of protein bands were quantified using densitometry. Results are expressed as multiples (×folds) of optical density of target protein and the alpha-tubulin determined in the control. The mean protein expression from the control was designated as 1 in the graph. Values (means ± S.D.) are representative of data obtained in three independent experiments (n = 3). Treatments not sharing a common letter are significantly different at P < 0.05 as assessed by one-way ANOVA followed by the Dunnett’s test.
