Figure 7 | Scientific Reports

Figure 7

From: Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice

Figure 7

Inhibition of mTORC1 or its upstream all downregulated the expansion of Th17 cells.

(A) Histopathological and immunohistochemistry findings (HE: ×200; IHC: ×400). The tan color indicates RORγt-positive staining. The arrows indicate positive cells. (B) The protein levels of PI3K/AKT- mTORC1 pathway and RORγt in injured lungs. (C) control; L: LPS; R: rapamycin; W: wortmannin. The mice were harvested on D2. All mice were wild type, with 3~5 mice per group.

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