Figure 9 | Scientific Reports

Figure 9

From: Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice

Figure 9

Rapamycin inhibited the proliferation of Th17 cells by up-regulating the expression of SOCS3 and Gfi1.

(A) The expression of SOCS3 and Gfi1 mRNA in the lungs. *p < 0.05, compared with the LPS-treated group. The error bars indicate SEM. (B) The protein levels of S6K1, SOCS3 and Gfi1 in the lungs. (C) The protein level of phosphorylated and total STAT3. (D) Differential expression of RORγt in cytoplasm and nucleus. C: control; L: LPS; R: rapamycin; W: wortmannin. The mice were harvested on D2. All mice were wild type, with 3~5 mice per group.

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