Figure 9 | Scientific Reports

Figure 9

From: Matrix metalloproteinase 12 modulates high-fat-diet induced glomerular fibrogenesis and inflammation in a mouse model of obesity

Figure 9

MMP-12 deletion attenuates HFD-induced oxidative damage in renal glomeruli.

Oxidative damage in apo E−/− and apo E−/−MMP-12−/− mice fed normal chow or HFD for 3, 6 and 9 months was assessed by detecting nitrotyrosine expression by immunohistochemistry. (B) Quantitative analysis of glomerular nitrotyrosine level expressed as a percentage of positive staining within the glomerulararea (10 glomeruli per kidney per animal). Values represent means ± SEM (n = 12 mice per group). *P < 0.05 vs. mice on normal chow; †P < 0.05 vs. mice on HFD at the same time point.

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