Figure 2 | Scientific Reports

Figure 2

From: Corticotropin releasing factor excites neurons of posterior hypothalamic nucleus to produce tachycardia in rats

Figure 2

CRF excited PH neurons with a direct postsynaptic manner.

(A1,A2) Graph of brain section shows the area of PH investigated in this study. (B1,B2) CRF still induce an inward current when perfusing the slice with TTX. (B3) Group data of the 5 recorded PH neurons in rats. (C1) CRF concentration-dependently excited PH neurons. (C2) Concentration-response curves for CRF on the 7 recorded PH neurons in rats shows the mean EC50 of 176.5 nM. In this and the following figures, the short horizontal bars above the data indicate the period of application of CRF or CRF receptor agonist and the long horizontal bars indicate the exposure of the slice to TTX and CRF receptor antagonist.

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