Figure 3
CRF excited PH neurons via CRFR1 and CRFR2.
(A) CRF excited PH neurons and highly selective agonists for CRFR1 and CRFR2, stressin I and urocortin II, respectively, mimicked the excitatory effect of CRF on PH neurons. (B) Selective CRFR1 antagonist antalarmin and selective CRFR2 antagonist antisavagine-30 partly blocked the excitation of PH neurons induced by CRF and in combination with antalarmin and antisavagine-30 totally blocked the neuronal excitation induced by CRF. (C) Group data of the tested PH neurons in rats. Statistical significance was determined using Student’s t test. **P < 0.01.
