Figure 4
From: Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis
Schematic illustration of the modulation of IL-1β in the tumor microenvironment to promote oral carcinogenesis.
Under carcinogenic stimulation, IL-1β is upregulated in both epithelial and stromal compartments such as fibroblasts. Paracrine signals from IL-1β activate gene expression pathways in neighboring cells and vice versa, ultimately setting up a cycle of reinforcement and generating a tumor favorable microenvironment for oral carcinogenesis.
