Table 1 Rank combination of dominant epitopes observed every year from 1999 to 2014.

From: Predicting the Mutating Distribution at Antigenic Sites of the Influenza Virus

Year

Epitope with Relative abundance a

Rank combination b

Year

Epitope with Relative abundance a

Rank combination b

1999c

54.55%

1,1,1,1,19

2007d

46.03%

1,2,2,1,6

2000c

30.68%

11,1,1,1,1

2008d

28.65%

1,1,2,1,--

17.05%

11,1,1,1,11

2009e

57.09%

2,1,1,1,1

2001c

51.15%

1,1,1,18,1

18.48%

1,1,1,1,1

2002c

31.25%

1,1,1,18,19

2010e

44.49%

2,1,1,1,1

18.75%

1,1,1,18,1

15.66%

2,1,1,1,24

2003c

46.94%

11,1,1,78,27

2011e

53.07%

2,1,1,1,24

34.69%

11,1,1,1,1

2012e

65.80%

2,1,1,1,24

2004c

50.00%

11,1,1,1,1

2013e

43.55%

2,1,1,39,24

25.00%

11,1,1,1,19

19.41%

2,1,1,1,24

2005c

77.78%

11,1,1,1,1

2014e

84.91%

2,1,1,39,24

2006c

28.32%

11,1,1,1,1

   
  1. aThe relative abundance of epitopes (combined by five antigenic sites) are generated from epitope sequence variation in reported strains every year. Dominant epitopes are listed with relative abundance above 15% in the yearly reported data during 1999–2014.
  2. bThe predicted combination rank of five sites are for Ca1, Ca2, Cb, Sa, Sb, respectively. Only mutants falling within top100 are recorded, otherwise represented by ‘--’.
  3. cThe combination rank during 1999–2006 are predicted by template A/New Caledonia/20/1999.
  4. dThe combination rank during 2007–2008 are predicted by template A/Solomon Islands/3/2006.
  5. eThe combination rank during 2009-2014 are predicted by template A/California/7/2009.
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