Figure 4
vlPAG resting state-functional connectivity comparison between acupuncture treament and waiting-list.
(A) Brain regions showed greater PAG rs-fc increase (post- minus pre-treatment) in the acupuncture treatment group compared to waiting-list control. (B) Partial regression between headache intensity changes and rs-fc value changes in acupuncture group (controlled for disease duration, SAS changes and SDS changes). (C) Increased resting state-functional connectivity between the vlPAG and rACC/VSt after treatment was associated with reduced headache intensity in patients received acupuncture treatment. L, left side; MwoA, migraine without aura; rACC, rostral anterior cingulate cortex; R, right side; VAS, visual analogue scale; vlPAG, periaqueductal gray; VSt, ventral striatum. (A) Brain region showed greater PAG rs-fc increase (post- minus pre-treatment) in the verum acupuncture treatment group compared to sham acupuncture group.
