Figure 7
From: Reducing central serotonin in adulthood promotes hippocampal neurogenesis
Altered anxiety- and depression-like behaviors and fear memory in hTM-DTAiPet1 mice.
(a) The time spent in the lit compartment is significantly increased in hTM-DTAiPet1 mice in the light/dark choice test, indicating reduced anxiety-like behaviors. Data were compared using Student’s t-test (p = 0.037). (b) The time spent in the open arms of the elevated plus maze is decreased in hTM-DTAiPet1 mice, but the difference is not statistically significant (p = 0.087). (c–d) Immobility time is significantly decreased in hTM-DTAiPet1 mice in the tail suspension test (c), but comparable between control and hTM-DTAiPet1 mice in the forced swim test (d). Data were compared using Student’s t-test (p = 0.0363 in d). (e–g) Enhanced fear memory in hTM-DTAiPet1 mice. Normal fear freezing is observed in hTM-DTAiPet1 mice on Day 0 (e). Data were compared using Two-way Repeated-Measures ANOVA. On Day 1 (f) and Day 30 (g), however, hTM-DTAiPet1 mice exhibit significantly increased contextual freezing. Data were compared using Student’s t-test (p = 0.017 in (f) and p = 8.2 × 10−4 in g). All data are presented as mean ± s.e.m. *p < 0.05; ***p < 0.001.
