Figure 3
Stratification analysis of the percentages of MAIT cells.
The CRC patients were stratified as early (I/II, n = 24) or advanced stage (III/IV, n = 24) and the percentages of MAIT cells in PBMC, NIL and TIL were compared with that in PBMC from 22 healthy controls (HC) and in LPMC from 13 non-tumor patients. Furthermore, the relationship among the percentages of MAIT cells in PBMC, NIL and TIL and the potential association between the percentages of MAIT cells in PBMC or TIL with the levels of serum CEA in individual groups of patients were analyzed. Finally, the percentages of circulating MAIT cells in five advanced CRC patients were characterized longitudinally by flow cytometry following different cycles of chemotherapies. Data are the mean values of individual subjects. (a) The frequencies of circulating MAIT cells. (b) The frequencies of MAIT cells in LPMC, NIL and TIL from early (n = 16) and advanced (n = 16) stage of CRC patients. (c) The percentages of circulating and tissue MAIT cells. (d) The relationship between the percentages of circulating and tissue MAIT cells. (e) The frequency of MAIT cells following chemotherapies. (f) The correlation between the levels of serum CEA and the percentages of MAIT cells in PBMC or TIL in the CRC patients.
