Figure 6 | Scientific Reports

Figure 6

From: Human monocytes undergo functional re-programming during differentiation to dendritic cell mediated by human extravillous trophoblasts

Figure 6

The modulating effect of EVTs on DCs is partially reversed by anti–MCP-1 and anti-M-CSF neutralizing Ab.

Neutralizing Abs against MCP-1 or M-CSF or both were added in HTR8-DC coculture system during the differentation of DCs. The isotype Abs were added as control at the same time. Cells from different culture were harvested at day 5 and the expression of CD14 (A), CD1a (B) and DC-SIGN (C) by the indicated DCs were summarized. The production of IL-10 (D) and IL-12 (E) by the indicated DCs upon LPS stimulation were measured and shown in the bar graph. Graphs show mean ± SEM of 5 individual experiments. *p < 0.05, **p < 0.01.

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