Table 1 Effect of inhibition of ABCG2, P-gp, and MRP1 on cytotoxicity (IC50, nM) of Jeg-3 and BeWo cells.

From: Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier

Cell line

Cytotoxic drug

IC50a

Cytotoxicity (nM) with inhibitors (1 μM)a

Ko-143

FTC

TQR

MK571

IC50

RIb

IC50

RIb

IC50

RIb

IC50

RIb

BeWo

SN-38

350.7 ± 71.9

23.8 ± 9.1***

14.7

53.7 ± 3.8**

6.5

–

–

–

–

Jeg-3

SN-38

15.0 ± 2.6

2.8 ± 0.4***

5.4

2.4 ± 0.3***

6.3

–

–

–

–

BeWo

Paclitaxel

2.9 ± 0.8

–

–

–

–

5.0 ± 0.3*

0.6

–

–

Jeg-3

Paclitaxel

7.7 ± 0.3

–

–

–

–

9.7 ± 1.4

0.8

–

–

BeWo

Doxorubicin

141.7 ± 6.1

–

–

–

–

–

–

114.4 ± 9.6*

1.2

Jeg-3

Doxorubicin

21.7 ± 3.7

–

–

–

–

–

–

17.4 ± 3.9

1.2

  1. aData represent three observations ± SD (*p < 0.05, **p < 0.01, **p < 0.001).
  2. bRelative Inhibition (RI) is calculated as the ratio of the IC50 of the uninhibited cell over the IC50 of the inhibited condition.
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