Figure 2
From: Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons
Cre recombination activity in the pancreatic islets of Ins2-Cre mice.
(a–b) Normal islet architecture of heterozygous Ins2-Cre mice demonstrated by HE staining (a) and double immunostaining for glucagon and insulin (b). DAPI was used for nuclear counterstaining. Scale bar, 100 μm. (c) Cre recombination activity in islets shown by X-gal staining in Ins2-Cre mice crossed onto Rosa-LacZ reporter line. Scale bar, 250 μm. (d) Cre recombination activity in islets shown by tdTomato fluorescence in Ins2-Cre mice crossed onto Rosa-tdTomato reporter line (Ai14). TdT, tdTomato. Scale bar, 200 μm.
