Table 3 Summary of ORs and 95% CI of IL-17A rs2275913 and IL-17F rs763780 polymorphisms with cancer risk.

From: Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis

Comparisons

B vs A

BB vs AA

BB vs AB + AA

BB + AB vs AA

AB vs AA

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

rs2275913

 Overall

1.22 (1.13–1.32)

<0.001

1.48 (1.25–1.74)

<0.001

1.40 (1.19–1.65)

<0.001

1.22 (1.09–1.36)

0.001

1.13 (1.01–1.28)

0.04

HWE

  Yes

1.23 (1.14–1.33)

<0.001

1.49 (1.27–1.75)

<0.001

1.39 (1.20–1.61)

<0.001

1.26 (1.14–1.38)

<0.001

1.17 (1.06–1.30)

0.002

Ethnicity

  Asian

1.22 (1.12–1.32)

<0.001

1.53 (1.29–1.81)

<0.001

1.45 (1.24–1.70)

<0.001

1.20 (1.06–1.35)

0.003

1.10 (0.97–1.24)

0.13

  Caucasian

1.24 (0.94–1.63)

0.13

1.16 (0.59–2.27)

0.66

1.08 (0.51–2.28)

0.84

1.34 (0.97–1.84)

0.07

1.35 (0.90–2.03)

0.14

Cancer type

  GC

1.24 (1.10–1.40)

<0.001

1.62 (1.26–2.07)

<0.001

1.56 (1.23–1.99)

<0.001

1.17 (0.99–1.38)

0.07

1.05 (0.89–1.25)

0.56

  CRC

1.25 (0.65–2.38)

0.51

0.61 (0.35–1.07)

0.09

0.48 (0.28–0.82)

0.007

1.71 (0.90–3.24)

0.10

2.10 (1.49–2.96)

<0.001

  CC

1.38 (1.18–1.62)

<0.001

1.89 (1.35–2.64)

<0.001

1.66 (1.23–2.24)

0.001

1.43 (1.14–1.80)

0.002

1.29 (1.01–1.64)

0.04

  HCC

0.99 (0.818–1.20)

0.89

0.96 (0.65–1.41)

0.82

1.03 (0.75–1.42)

0.85

0.94 (0.68–1.28)

0.68

0.92 (0.66–1.29)

0.63

rs763780

 Overall

1.28 (1.11–1.47)

0.001

1.69 (1.40–2.04)

<0.001

1.64 (1.36–1.97)

<0.001

1.25 (1.07–1.47)

0.001

1.17 (1.00–1.37)

0.06

HWE

  Yes

1.25 (1.02–1.52)

0.03

1.70 (1.21–2.39)

0.002

1.69 (1.20–2.38)

0.002

1.21 (0.98–1.50)

0.08

1.15 (0.93–1.41)

0.20

Ethnicity

  Asian

1.06 (0.95–1.19)

0.28

1.54 (1.08–2.20)

0.02

1.55 (1.09–2.20)

0.02

1.04 (0.87–1.24)

0.66

0.99 (0.83–1.19)

0.95

 Caucasian

2.08 (0.94–1.63)

0.03

6.17 (1.50–30.0)

0.01

6.19 (1.36–28.1)

0.02

2.02 (1.08–3.76)

0.03

1.83 (1.08–3.11)

0.02

Cancer type

  GC

1.37 (1.25–1.51)

<0.001

1.67 (1.35–2.06)

<0.001

1.59 (1.29–1.95)

<0.001

1.37 (1.22–1.53)

<0.001

1.28 (1.13–1.45)

<0.001

  CRC

1.40 (0.65–3.00)

0.38

–

–

–

–

1.43 (0.63–3.22)

0.39

1.42 (0.63–3.24)

0.40

  1. A: the major allele; B: the minor allele; CI: confidence interval; OR: odds ratio; GC: Gastric cancer; CRC: colorectal cancer; CC: cervical cancer; HCC: hepatocellular carcinoma.
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