Table 4 Heterogeneity-analysis results.

Comparisons	B vs A			BB vs AA			BB vs AA+AB			BB+AB vs AA			AB vs AA
Comparisons	I²	P	EM	I²	P	EM	I²	P	EM	I²	P	EM	I²	P	EM
rs2275913
Overall	61%	<0.001	R	64%	<0.001	R	70%	<0.001	R	60%	<0.001	R	62%	<0.001	R
HWE
Yes	58%	0.001	R	57%	0.001	R	60%	<0.001	R	43%	0.02	R	39%	0.04	R
Ethnicity
Asian	62%	<0.001	R	63%	<0.001	R	68%	<0.001	R	62%	<0.001	R	60%	<0.001	R
Caucasian	68%	0.01	R	72%	0.007	R	80%	0.001	R	58%	0.05	R	70%	0.009	R
Cancer type
GC	74%	<0.001	R	75%	<0.001	R	79%	<0.001	R	73%	<0.001	R	71%	<0.001	R
CRC	84%	0.01	R	0%	0.48	F	0%	0.61	F	74%	0.05	R	14%	0.28	F
CC	0%	0.45	F	0%	0.40	F	0%	0.47	F	0%	0.51	F	0%	0.51	F
HCC	0%	0.93	F	0%	0.88	F	0%	0.56	F	0%	0.43	F	8%	0.30	F
rs763780
Overall	68%	<0.001	R	0%	0.79	F	0%	0.79	F	64%	<0.001	R	57%	0.001	R
HWE
Yes	68%	<0.001	R	0%	0.79	F	0%	0.82	F	66%	<0.001	R	61%	0.002	R
Ethnicity
Asian	37%	0.12	F	0%	0.94	F	0%	0.93	F	43%	0.08	R	44%	0.08	R
Caucasian	78%	0.003	R	17%	0.30	F	5%	0.35	F	72%	0.02	R	59%	0.06	R
Cancer type
GC	31%	0.17	F	6%	0.79	F	0%	0.72	F	10%	0.36	F	0%	0.48	F
CRC	66%	0.09	R	–	–	–	–	–	–	67%	0.08	R	67%	0.08	R

A: the major allele; B: the minor allele; EM: Effects model; F: fixed effects model; R: random effects model; GC: Gastric cancer; CRC: colorectal cancer; CC: cervical cancer; HCC: hepatocellular carcinoma.

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